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Check Carefully (three)pentobarbital will minimize the level or impact of diazepam intranasal by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Observe. Solid or average CYP3A4 inducers may enhance rate of diazepam elimination; consequently, efficacy of diazepam may be lowered.pentobarbital will reduce the level or outcome of br